The San Francisco 49ers (10-4) will be monitoring three players on their injury report going into a Monday, Dec. 22 game against the Indianapolis Colts (8-6) at Lucas Oil Stadium, due to start at 8:15 p.m. ET. The Colts currently have five players listed on their report.
How to Watch 49ers vs. Colts
Game date: Monday, December 22, 2025
Time: 8:15 p.m. ET
Venue: Lucas Oil Stadium
Location: Indianapolis, Indiana
TV: ESPN
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The Indianapolis Colts (8-6) will have their eyes set on rebounding from their four-game losing streak when they take on the San Francisco 49ers (10-4) at Lucas Oil Stadium on Monday, December 22, 2025.
49ers vs. Colts Odds
Point Spread
The spread for this matchup is set at 5.5 points, with sportsbooks listing the 49ers as the favorites.
Moneyline
As for the moneyline, the 49ers have -258 odds to pick up the win, while the Colts are listed at +209 to claim victory.
Over/Under
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San Francisco 49ers tight end Jake Tonges will match up with the 31st-ranked passing defense of the Indianapolis Colts (247.6 yards allowed per game) in Week 16, at 8:15 p.m. ET on Monday.
With his upcoming matchup against the Colts this week, should Tonges be considered a lock for your fantasy football lineup? We dissect the stats and trends below.
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Jake Tonges Week 16 Game Info
Let’s highlight a few of the...
Kendrick Bourne and the San Francisco 49ers will play the Indianapolis Colts and their 31st-ranked passing defense (247.6 yards conceded per game) in Week 16, on Monday at 8:15 p.m. ET.
With his upcoming game versus the Colts this week, should Bourne be considered a lock for your fantasy football lineup? We dissect the stats and trends below.
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Kendrick Bourne Week 16 Game Info
Let’s highlight a few of the up...
In Week 16 (Monday at 8:15 p.m. ET), wide receiver Demarcus Robinson and the San Francisco 49ers will meet the Indianapolis Colts, who have the 31st-ranked passing defense in the NFL (247.6 yards allowed per game).
Is Robinson’s game against the Colts this week a good time to start him in fantasy? Below, we highlight his relevant fantasy statistics.
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Demarcus Robinson Week 16 Game Info
Let’s go into a few of...
The San Francisco 49ers are inching closer and closer to a playoff berth, getting the chance to clinch their spot in the postseason with a win over the Indianapolis Colts on Monday Night Football in Week 16. To do so, they’ll have to get through Jonathan Taylor, who has been the NFL’s best running back […]
49ers’ Ricky Pearsall out for Monday’s game at Colts with knee injury (paywall)“Kyle Shanahan said Pearsall came close to playing versus the Colts. But he didn’t practice this week and was limited to sprinting on a side field during Friday’s session. “He was close, but not close enough,” Shanahan said.“ 49ers vs. Colts: The Standard’s […]
In Week 16 (Monday at 8:15 p.m. ET), wideout Josh Downs and the Indianapolis Colts will face the San Francisco 49ers, who have the 22nd-ranked pass defense in the NFL (227.6 yards conceded per game).
Is Downs’ game against the 49ers this week a good time to start him in fantasy? Below, we break down his relevant fantasy statistics.
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Josh Downs Week 16 Game Info
Let’s go into a few of the upcoming game’s key ...
The San Francisco 49ers (10-4) will visit the Indianapolis Colts (8-6) on Monday at 8:15 p.m. ET. Keep scrolling for DFS analysis.
49ers vs. Colts Game Info
When: Monday, December 22, 2025 at 8:15 p.m. ET
Where: Lucas Oil Stadium in Indianapolis, Indiana
TV info: ESPN
Live Stream: Watch this game on Fubo (Regional restrictions apply)
49ers DFS Projections
Salary values from DraftKings.
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The Indianapolis Colts today released their Saturday injury report for Week 16 of the NFL season against the San Francisco 49ers for Monday night. Defensive tackle Deforest Buckner has been listed as QUESTIONABLE for Monday’s games against the 49ers with a neck injury. Buckner looks set to return from injured reserve this week and provide […]
The San Francisco 49ers placed linebacker Nick Martin on the Injured Reserve. He’s been out since he suffered a concussion in Week 15. After being limited this week during practice, it’s likely the 49ers activate defensive lineman Yetur Gross-Matos from the Injured Reserve as the corresponding move. Ricky Pearsall didn’t practice for the third straight […]
The San Francisco 49ers are back in primetime in Week 16, taking on the Indianapolis Colts on the road on Monday Night Football. After the Seattle Seahawks won against the Los Angeles Rams in a thriller on Thursday night, the path to the No. 1 seed cleared up for San Francisco: win out and get […]
The Indianapolis Colts ruled out cornerback Sauce Gardner ahead of Monday Night Football. It’s not often that the San Francisco 49ers catch an injury break, but this is one of them. Former Niner and All-Pro cornerback Charvarius Ward was placed on the Injured Reserve on December 10 after his third concussion of the season. Gardner […]
According to head coach Shane Steichen, Indianapolis Colts defensive tackle DeForest Buckner (neck) will play against his former team on Monday Night Football this week (via ESPN’s Adam Schefter). The Pro Bowl veteran defensive tackle has not played since Week 9 at the Pittsburgh Steelers, when he injured his neck and was placed on injured […]
Earlier this season, I wrote that Daniel Jones was playing himself into a massive new contract. He was on a one-year, $14 million deal and had completely transformed the Colts’ offense, turning them into one of the most efficient scoring units in the league. Based on the level he was playing at, I projected that […]
When the Seattle Seahawks beat the Indianapolis Colts, I said the game was largely lacking in big action moments. There was only one touchdown scored, one turnover on the Colts’ final play, and not a lot of explosive highlights on offense or defense to talk about. The Los Angeles Rams game made up for that […]
DeForest Buckner FULL GO at Colts practice! Time for Uncle Philip Rivers to step UP!
The stage is set. Monday Night Football in Indianapolis. Philip Rivers starts his second game for the Colts, and a 49ers win clinches a playoff berth. DeForest Buckner should be activated off IR, setting up an old friend scenario. Unfortunately, Charvarius Ward was placed on IR, so that reunion won’t happen. The 49ers are looking […]
The San Francisco 49ers are one win away from a playoff berth, which could come as early as this Monday against the Indianapolis Colts, placing them back in the postseason after a one-year hiatus. It’s been a much different year for the 49ers, who have dealt with major injuries on both sides of the ball, […]
Philip Rivers feels great, ready for week two, and to get three Colts wins!
The Indianapolis Colts are still alive in the playoff chase. If they win their next three games there is a really good chance they at least make the final wild card spot. Considering where things were to start the year, that is highly disappointing. Considering where things have been the last month, they’ll take it. […]
Lets start with the elephant in the room. The three remaining teams on the schedule, are a combined 29 – 13. Two of those teams have beaten the Colts in the last three weeks and the third team is from the strongest division in the league and has every reason to treat the game as […]
The recent return of Phillip Rivers to the Indianapolis Colts prompts consideration of which players might be pulled out of retirement to help other teams in the league. Given the dysfunction that the Cleveland Browns have had over the years, there aren’t many great players who have spent a large portion of their career dominating in Cleveland. […]
Indianapolis, IN — Indianapolis Colts second-year defensive end Laiatu Latu already has more sacks than he did as a rookie, poised to lead the team in sacks as they enter the final stretch of the regular season. Despite this progression on the surface, some fans and analysts seem to think that Latu will never take […]
Colts Run game MUST explode vs SF! IU Football rewards Haines, Shanahan! Pacers lose!