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Colts-Jaguars opening odds: This could be it

The Indianapolis Colts are meeting a familiar face in a must win game in week seventeen. If the game against the 49ers wasn’t brutal enough for the defense, this one might be worse as the Jaguars are rolling into town red-hot. This is an absolute must win for the Colts. A win this week, coupled […]

Golden Nuggets: Victory Tuesday!

Brock Purdy and Christian McCaffrey have big night against Colts“McCaffrey, who racked up 117 yards on 21 carries, surpassed 1,000 rushing yards for the season, the fifth time he has done it in his career.” The 49ers want you to believe they don’t need a defense“The positives for that group were that CJ West and […]

Colts lose fifth straight to 49ers on MNF as playoff hopes hang by a thread

The tightrope finally snapped inside Lucas Oil Stadium on Monday Night Football as the Indianapolis Colts suffered a fifth straight loss in a 48-27 blowout against the San Francisco 49ers. What began as a hopeful holiday stage to showcase what was the league’s most explosive offensive unit entering the Week 11 BYE, has turned into […]

Colts QB Philip Rivers finds fountain of youth in primetime, but Indy defense lays major dud vs. 49ers

The desperate Indianapolis Colts (8-7) were fighting for their increasingly slim playoff odds, but if you want to blame someone after falling to the San Francisco 49ers (11-4), 48-27, on Monday Night Football, don’t blame grizzled veteran Philip Rivers (i.e., ‘Grandpa Phil’). The 44-year-old longtime veteran quarterback, who shockingly unretired two weeks ago and had […]

49ers playoff picture: What a win over the Colts means for the NFC Standings

The Seattle Seahawks looked like a team that didn’t trust its quarterback. They were running the ball in situations perceived as passing. Sam Darnold threw two costly interceptions when Seattle let him throw. They couldn’t have happened at worse times. On the flipside, Matthew Stafford and Puka Nacua of the Los Angeles Rams connected for […]

Colts playoff picture: What Week 16 vs. 49ers means for AFC standings

Game result: The Colts came up short against the 49ers and dropped to 8-7 with the loss. They are officially eliminated from AFC South contention, but remain alive in the wild card race. They are two games back of the Texans. The Colts host the Jaguars and travel to face the Texans the final two […]

Brock Purdy’s 5 touchdowns lead the 49ers to a blowout win over the Colts

The Indianapolis Colts only attempted two passes beyond 20 yards against the Seattle Seahawks in Week 15. On the first play from scrimmage against the San Francisco 49ers, Philip Rivers “let it fly.” His first throw traveled 45 yards. That would be the last mistake Rivers made on the drive. Tatum Bethune was on Jonathan […]

Chargers playoff picture: Los Angeles clinches playoff spot with Colts loss on ‘Monday Night Football’

The Los Angeles Chargers clinched a playoff spot on Monday without even playing in the game. The Indianapolis Colts lost to fellow playoff hopefuls in the San Francisco 49ers. The game isin Indianapolis featured former Chargers quarterback Phillip Rivers as Indy’s starting QB. Updated AFC standings How the Chargers clinched a playoff spot Now that […]

Philip Rivers took the 49ers to school on Colts opening drive

Indianapolis, IN — Clinical, surgical, teach tape: these are just a few words that accurately describe Philip Rivers’s opening drive in primetime against the San Francisco 49ers. Starting center Tanor Bortolini went down early with a concussion, making it the Colts’ third consecutive week in which a starting offensive lineman left the game with injury, […]

49ers can knock Rams down a peg tonight

If the San Francisco 49ers beat the Indianapolis Colts on Monday, the Los Angeles Rams will slip from the 5 seed to the 6 seed in the NFC playoff picture. It’s a remarkable turnaround from where these teams were at going into their Week 5 matchup — an overtime win by the 49ers — and […]

49ers vs. Colts: Monday Night Football Game Discussion

The Indianapolis Colts host the San Francisco 49ers in Indy. These teams are on vastly different trajectories, as the Niners are on a four-game winning streak and Indy is on a four-game losing streak. Will San Francisco make it five-straight? Can Indy avoid five-straight? Let’s tune in to find out! San Francisco 49ers at Indianapolis Colts Lucas […]

49ers-Colts game thread: Tonight will come down to red zone execution

For all of the talk about how the San Francisco 49ers still need to win. And despite playing a quarterback who is projected to throw for 159 yards tonight, this will not be an easy game. The Indianapolis Colts have several weapons at Philip Rivers’ disposal, and the best one is at running back. Jonathan […]

Buffalo Bills fan discussion: Playoff picture chat with Indianapolis Colts on ‘Monday Night Football’

After tonight, there’s just two weeks left on the 2025 NFL regular-season schedule. To wrap up Week 16, we get a Monday Night Football matchup between the Indianapolis Colts and San Francisco 49ers that should hold everyone’s interests. If you’re looking for Buffalo Bills-related playoff rooting interests, the task is simple: With a Colts loss, […]

49ers vs. Colts: Monday Night Football

Week 16 of the 2025 NFL season ends tonight with a Monday Night Football game between the San Francisco 49ers and Indianapolis Colts. The Philadelphia Eagles’ chances of getting the No. 1 seed are incredibly slim (like, 0.1% chance slim) but the Birds will remain mathematically alive for a first-round bye if the 49ers lose […]

49ers vs. Colts live discussion: Philip Rivers can help the Seahawks

Okay, so Philip Rivers almost had a dream comeback after ending his five-year retirement to play for the Indianapolis Colts. The Seattle Seahawks thwarted Rivers with an 18-16 victory thanks to six Jason Myers field goals. Philip Rivers is 4-0 against the San Francisco 49ers. A win for the Colts at home on Monday Night […]

49ers at Colts, Week 16 MNF fan discussion

Week 16 comes to a close with a “Monday Night Football” matchup featuring the San Francisco 49ers (10-4) and the Indianapolis Colts (8-6). The 49ers have clinched a playoff berth in the NFC Playoffs—the Detroit Lions can only hope to tie their record, and San Francisco holds the tie-breaker, so they’re in—but they’re still fully […]

Monday Night Football: Colts vs. 49ers – Lineups, Broadcast Info, Game Thread, More

Week 16 concludes this evening, with the Colts taking on the 49ers on Monday Night Football. How to Watch Monday Night Football: Colts vs. 49ers TV: ABC Streaming: NFL+ Radio: Westwood One Kickoff Time: 7:15 PM CT Site: Lucas Oil Stadium, Indianapolis, IN. Referee: Ron Torbert Odds : 49ers -5.5, O/U 45.5 ( via DraftKings Sportsbook ) Kevin Ng-Imagn Images Colts Projected Starters Offense QB  – Philip Rivers RB  – Jonath...

bet365 Bonus Code BNATION Earns $150 for Monday Night Football and More

Monday night brings some solid sports action, and a bet365 bonus code can be used for any matchup. This gets you $150 in bonus bets for games like the 49ers taking on the Colts. bet365 Bonus Code BNATION New users can register with the bonus code BNATION to score the bonus. Sign up with BNATION on bet365. 21+ to wager (18+ in Kentucky). Geolocation confirms if you can bet in your state. Make a deposit. Place a $5 bet… First wager must be -500 od...