In Week 16 (Monday at 8:15 p.m. ET), wideout Josh Downs and the Indianapolis Colts will face the San Francisco 49ers, who have the 22nd-ranked pass defense in the NFL (227.6 yards conceded per game).
Is Downs’ game against the 49ers this week a good time to start him in fantasy? Below, we break down his relevant fantasy statistics.
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Josh Downs Week 16 Game Info
Let’s go into a few of the upcoming game’s key ...
From Bleacher Nation | Chicago Sports News, Rumors, and a Reasonable Level of Obsession
| about 2 months ago
| 4 reads
The San Francisco 49ers (10-4) will visit the Indianapolis Colts (8-6) on Monday at 8:15 p.m. ET. Keep scrolling for DFS analysis.
49ers vs. Colts Game Info
When: Monday, December 22, 2025 at 8:15 p.m. ET
Where: Lucas Oil Stadium in Indianapolis, Indiana
TV info: ESPN
Live Stream: Watch this game on Fubo (Regional restrictions apply)
49ers DFS Projections
Salary values from DraftKings.
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Position
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Projected Points per 1K
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From Bleacher Nation | Chicago Sports News, Rumors, and a Reasonable Level of Obsession
| about 2 months ago
| 1 read
The Indianapolis Colts today released their Saturday injury report for Week 16 of the NFL season against the San Francisco 49ers for Monday night. Defensive tackle Deforest Buckner has been listed as QUESTIONABLE for Monday’s games against the 49ers with a neck injury. Buckner looks set to return from injured reserve this week and provide […]
From Stampede Blue
| about 2 months ago
| 1 read
The San Francisco 49ers placed linebacker Nick Martin on the Injured Reserve. He’s been out since he suffered a concussion in Week 15. After being limited this week during practice, it’s likely the 49ers activate defensive lineman Yetur Gross-Matos from the Injured Reserve as the corresponding move. Ricky Pearsall didn’t practice for the third straight […]
From Niners Nation
| about 2 months ago
| 1 read
The San Francisco 49ers are back in primetime in Week 16, taking on the Indianapolis Colts on the road on Monday Night Football. After the Seattle Seahawks won against the Los Angeles Rams in a thriller on Thursday night, the path to the No. 1 seed cleared up for San Francisco: win out and get […]
From Niners Nation
| about 2 months ago
| 1 read
The Indianapolis Colts ruled out cornerback Sauce Gardner ahead of Monday Night Football. It’s not often that the San Francisco 49ers catch an injury break, but this is one of them. Former Niner and All-Pro cornerback Charvarius Ward was placed on the Injured Reserve on December 10 after his third concussion of the season. Gardner […]
From Niners Nation
| about 2 months ago
| 1 read
The 49ers have voided Brandon Aiyuk’s guaranteed money. A decision made after he stopped coming to the facility, communicating with the team, and long after the team had already lost several contributors in 2025 free agency. By the time all of that happened, the 49ers weren’t just losing players — they were losing margin for […]
From Niners Nation
| about 2 months ago
| 1 read
Yeah, it’s back. Chill out. Listen, I’ve been on the road with this column for over six years. I needed a break and, honestly, I wouldn’t have brought it back if at least one person hadn’t messaged and said: “Where’s the column gone Ben?” So here we are, the first one since the Dons cup […]
From The Tilehurst End
| about 2 months ago
| 1 read
Saleh, Kubiak, Purdy preview 49ers-Colts Week 16 matchup“Because the defense is still maturing, do you have to remind them, don’t look ahead? “No. These guys, they go through their process, we’re human. I can assure you that a lot of the guys were watching the game last night. We’d be lying if we said we […]
From Niners Nation
| about 2 months ago
| 2 reads
DeForest Buckner playing Monday? Sounds like he’s thinking about quality of life, not play!
From KentSterling.com
| about 2 months ago
| 0 reads
The stage is set. Monday Night Football in Indianapolis. Philip Rivers starts his second game for the Colts, and a 49ers win clinches a playoff berth. DeForest Buckner should be activated off IR, setting up an old friend scenario. Unfortunately, Charvarius Ward was placed on IR, so that reunion won’t happen. The 49ers are looking […]
From Niners Nation
| about 2 months ago
| 2 reads
The San Francisco 49ers have three more games remaining and all of them could be on national TV. After the Los Angeles Rams lost to the Seattle Seahawks on Thursday night, it opened the door for the 49ers. Both the 49ers and Seahawks now control their destiny for the No. 1 seed and the NFC […]
From Niners Nation
| about 2 months ago
| 3 reads
The San Francisco 49ers are one win away from a playoff berth, which could come as early as this Monday against the Indianapolis Colts, placing them back in the postseason after a one-year hiatus. It’s been a much different year for the 49ers, who have dealt with major injuries on both sides of the ball, […]
From Niners Nation
| about 2 months ago
| 4 reads
The San Francisco 49ers are firmly in the mix for a playoff spot, having the opportunity to clinch a postseason berth with a win over the Indianapolis Colts this weekend. It’s been an impressive season for San Francisco, which has overcome injuries and gotten hot at the right time, winning its last four games against […]
From Niners Nation
| about 2 months ago
| 2 reads
Colts Run game MUST explode vs SF! IU Football rewards Haines, Shanahan! Pacers lose!
From KentSterling.com
| about 2 months ago
| 11 reads
Seahawks beat Rams in thriller: What the NFC West shift means for the 49ers“If the 49ers win out—including what could be a pivotal Week 18 matchup against Seattle at Levi’s Stadium—they would have a legitimate claim to the top spot in the conference. A win in Week 18 would mean the 49ers sweep the Seahawks […]
From Niners Nation
| about 2 months ago
| 2 reads
It will be tough for the Los Angeles Rams to recover from their 37-38 overtime loss to the Seattle Seahawks. The Rams fall to 11-4. Seattle swells to 12-3. Los Angeles is now unlikely to win either the NFC conference or the NFC West division. Simply put, Seattle and the San Francisco 49ers have a […]
From Turf Show Times
| about 2 months ago
| 3 reads
Over five weeks ago, fresh off the San Francisco 49ers losing 42-26 to the Los Angeles Rams, the talk of any playoffs was frowned upon. If you had known the Niners still had an opportunity to earn the No. 1 seed, you would have laughed. Here we are, heading into Week 16, with that slight […]
From Niners Nation
| about 2 months ago
| 3 reads
Flashback to March 16, 2020. A few days after the San Francisco 49ers reached a five-year extension with Arik Armstead, the team traded DeForest Buckner to the Indianapolis Colts in exchange for a top-15 pick. The Colts made Buckner the second-highest-paid defensive tackle in the NFL behind Aaron Donald at the time. Buckner wanted Donald […]
From Niners Nation
| about 2 months ago
| 7 reads
San Francisco 49ers rookie linebacker Nick Martin remains in the concussion protocol. Defensive tackle Jordan Elliott won’t practice on Thursday with a knee injury, while left guard Spencer Burford (knee/ankle) will also sit out of practice. Burford not practicing explains the pair of tryouts the Niners recently had at offensive line. If he can’t go, […]
From Niners Nation
| about 2 months ago
| 3 reads
ESPN’s Seth Walder used their FPI simulation for the last three weeks of the season and came up with the most likely field of 14 playoff teams and exact seeding order for each team in each conference. In addition to the regular season standings and playoff bracket, they projected the Super Bowl LX winner. The […]
From Niners Nation
| about 2 months ago
| 3 reads
The Los Angeles Rams and Seattle Seahawks will compete on Thursday Night Football in Week 16 with both teams sitting at 11-3. Winning this game means getting an advantage in the race for both the No. 1 seed in the NFC and the NFC West. However, a Rams loss would open the door for a […]
From Turf Show Times
| about 2 months ago
| 3 reads
Down the stretch they come. The 49ers’ final three-game stretch kicks off Monday night in Indianapolis as Philip Rivers tries to keep the Colts’ playoff chances alive. Given the struggles slowing down the run, Jonathan Taylor and the Colts’ rushing attack provide a concerning challenge for the 49ers’ run defense. On the other side of […]
From Niners Nation
| about 2 months ago
| 3 reads
The San Francisco 49ers are still firmly in the mix for a playoff spot, getting the chance to clinch a berth this weekend with a win over the Indianapolis Colts. But, that doesn’t mean we can’t look ahead and project to the 2026 offseason, which will almost assuredly be a game-changer for the 49ers. After […]
From Niners Nation
| about 2 months ago
| 2 reads
The San Francisco 49ers are just three weeks away from the postseason, with the chance to clinch a playoff berth this weekend with a win over the Indianapolis Colts. At 10-4, the 49ers have well exceeded expectations this season, especially with the injuries they’ve faced. But, the job isn’t done. San Francisco still has a […]
From Niners Nation
| about 2 months ago
| 4 reads